WK 11 KC

12. 1. Discuss the genetic basis for sickle cell disease (SCD). 2. Explain the pathophysiology of acyte SCD crisis. Why is pain the predominate feature of acute crises? 3. What is the pathophysiology of Hemophilia.

The most frequent genetic blood disease in the US is sickle cell disease. More than 100,000 Americans suffer from it. African Americans are the group within the United States most likely to suffer from sickle cell disease. One hundred Hispanic Americans and one in twelve African Americans have the sickle cell disorder, meaning the are sickle cell carriers. A change in the hemoglobin-Beta gene on chromosome 11 , results with sickle-cell disease (Inusa and co. 2019, 2019). Oxygen is carried around the body via hemoglobin that comes from the lung. Hemoglobin-A-containing red blood cells are spherical and smooth and float in blood arteries. Hemoglobin S, which is an unnatural hemoglobin molecule, binds with other molecules of hemoglobin in patients with sickle cell disease and creates long rod-like structures. Red blood cells acquire these characteristics, making them hard and sickle-like. The red blood cells build up due to their shape that causes obstructions and damage to tissues and organs of importance. Cont…

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